Institutional Repository
Technical University of Crete
Technical University of Crete
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EL
| URI | http://purl.tuc.gr/dl/dias/2C2A35DF-0DA9-4360-B3A3-FA49ECE089FE | - |
| Identifier | https://doi.org/10.1111/j.1471-0528.2012.03280.x | - |
| Language | en | - |
| Title | Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: A clinical trial using dynamic spectral imaging colposcopy | en |
| Creator | Balas Costas | en |
| Creator | Μπαλας Κωστας | el |
| Creator | Papagiannakis Emmanouil | en |
| Creator | Παπαγιαννακης Εμμανουηλ | el |
| Creator | A. Zaal | en |
| Creator | Jacqueline Agnes Louwers | en |
| Creator | J. Berkhof | en |
| Creator | Mariëlle Kocken | en |
| Creator | W. A. Harmsel | en |
| Creator | G. C. M. Graziosi | en |
| Creator | J. W. M. Spruijt | en |
| Creator | Mariëlle Kocken | en |
| Creator | P. J. F. Snijders | en |
| Creator | C. J. L. M. Meijer | en |
| Creator | Fj van Kemenade | en |
| Creator | R. H. M. Verheijen | en |
| Content Summary | To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16-positive (HPV16(+)) and non-16 high-risk (hr) HPV(+) women. Prospective, comparative, multicentre clinical trial. Three colposcopy clinics in the Netherlands. Women (n = 177) aged 18 years or over with an intact cervix, referred for colposcopy. The colposcopist graded the lesion by using the DSI colposcope as a regular video colposcope. Subsequently the DSI impression was displayed and biopsies were taken from all abnormal areas as well as from a random (normal) site. A cervical smear was taken for HPV typing. Histologically confirmed high-grade cervical intraepithelial neoplasia or cancer (CIN2(+)), positive for HPV16 or for any other hrHPV type. The DSI colposcope identified more CIN2(+) cervical lesions among HPV16(+) women than in non-16 hrHPV(+) women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2(+)). Consequently, the sensitivity of the DSI colposcope for detecting CIN2(+) lesions was higher in HPV16(+) women than in non-16 hrHPV(+) women (97% versus 74%, P = 0.009). No such differences were seen for the colposcopist impression. In addition, mainly smaller cervical lesions are missed by the colposcopist. The sensitivity of DSI colposcopy for CIN2(+) is higher in HPV16(+) than in non-16 hrHPV(+) women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2(+) is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions. | en |
| Type of Item | Peer-Reviewed Journal Publication | en |
| Type of Item | Δημοσίευση σε Περιοδικό με Κριτές | el |
| License | http://creativecommons.org/licenses/by/4.0/ | en |
| Date of Item | 2015-10-17 | - |
| Date of Publication | 2012 | - |
| Bibliographic Citation | A. Zaal, J. A. Louwers, J. Berkhof, M. Kocken, W.A. Harmsel, G.C.M. Graziosi, J. W.M. Spruijt, C. Balas, E. Papagiannakis, P. J. F. Snijders, C.J.L.M. Meijer, F.J. van Kemenade, R. H. M. Verheijen. "Agreement between colposcopic impression and histological diagnosis among HPV16 positive women: a clinical trial using dynamic spectral imaging colposcopy". BJOG. Feb. 2012, Vol. 119, Iss. 5, pp. 537-44. DOI: 10.1111/j.1471-0528.2012.03280 | en |
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