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In silico modeling and global optimization of dynamic bio-optical processes for probing, in vivo, biological features of neoplasia

Balas Costas, Papoutsoglou Georgios, Stamatiadou M.

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Περίληψη

We present the first in silico simulation of biomarker uptake kinetics and of the associated dynamic optical signals, measured in vivo in neoplastic epithelial tissue. We introduce a new, non-invasive method for estimating and mapping of both structural and functional, neoplasia-correlated parameters. The method relies on model-based fitting of dynamic optical signals, measured in vivo, and on solving the inverse problem with the aid of global sensitivity analysis and global optimization approaches.

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