Institutional Repository
Technical University of Crete
Technical University of Crete
EN
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EL
| URI | http://purl.tuc.gr/dl/dias/B30F7A58-E40E-45D7-A508-C1EC4C018543 | - |
| Identifier | https://doi.org/10.1109/IEMBS.2011.6089905 | - |
| Language | en | - |
| Title | In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia | en |
| Creator | Balas Costas | en |
| Creator | Μπαλας Κωστας | el |
| Creator | Papoutsoglou Georgios | en |
| Creator | Παπουτσογλου Γεωργιος | el |
| Creator | Anastasopoulou Angeliki | en |
| Creator | Αναστασοπουλου Αγγελικη | el |
| Creator | Stavrakakis Georgios | en |
| Creator | Σταυρακακης Γεωργιος | el |
| Creator | W.P. Soutter | en |
| Publisher | Institute of Electrical and Electronics Engineers | en |
| Content Summary | We present a method for detecting and studying neoplasia-specific functional and structural features through the combination of in vivo dynamic imaging, in silico modeling and global sensitivity analysis. We particularly present the case of cervical epithelium interacting with acetic acid solution, which is employed as an optical biomarker. The in vivo measured dynamic scattering characteristics are strongly correlated with the output of the biomarker's pharmacokinetic model that we have developed. Model global sensitivity analysis has shown that the measured/modeled bio-optical processes can be used for probing, in vivo, the number of neoplastic layers, the extracellular pH, the intracellular buffering efficiency and the size of the extracellular space. | en |
| Type of Item | Peer-Reviewed Journal Publication | en |
| Type of Item | Δημοσίευση σε Περιοδικό με Κριτές | el |
| License | http://creativecommons.org/licenses/by/4.0/ | en |
| Date of Item | 2015-10-19 | - |
| Date of Publication | 2011 | - |
| Bibliographic Citation | G. Papoutsoglou, A. Anastasopoulou, G. Stavrakakis, W.P. Soutter and C. Balas, "In vivo Dynamic Imaging, in silico Modeling and Global Sensitivity Analysis for the Study and the Diagnosis of Epithelial Neoplasia" 33rd Annual International Conference of the IEEE EMBS Boston, Massachusetts USA, Aug. 30 - Sept. 3, 2011, doi: 10.1109/IEMBS.2011.6089905 | en |
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