Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
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| URI | http://purl.tuc.gr/dl/dias/8A0548BD-98D6-4A5E-A110-00BB84DB0569 | - |
| Αναγνωριστικό | https://doi.org/10.1016/j.apmt.2023.102006 | - |
| Αναγνωριστικό | https://www.sciencedirect.com/science/article/pii/S2352940723002755 | - |
| Γλώσσα | en | - |
| Μέγεθος | 9 pages | en |
| Τίτλος | Synthesis, characterization, and biocompatibility studies of a new lanthanum-cerium synthetic aminoclay analogue | en |
| Δημιουργός | Kaloudi Angela S. | en |
| Δημιουργός | Athinodorou Antrea Maria | en |
| Δημιουργός | Spyrou Konstantinos | en |
| Δημιουργός | Simos Yannis V. | en |
| Δημιουργός | Zygouri Panagiota | en |
| Δημιουργός | Hammami Mohamed Amen | en |
| Δημιουργός | Datta K. K. R. | en |
| Δημιουργός | Vezyraki Patra E. | en |
| Δημιουργός | Peschos Dimitrios | en |
| Δημιουργός | Tsamis Konstantinos | en |
| Δημιουργός | Gournis Dimitrios | en |
| Δημιουργός | Γουρνης Δημητριος | el |
| Εκδότης | Elsevier | en |
| Περίληψη | Aminopropyl-functionalized synthetic phyllosilicate analogues have been widely used in many biological and medical applications due to their facile, green, simple and at ambient conditions synthetic procedure. Furthermore, rare earth synthetic aminoclay analogues could have great potential as antibacterial agents, since rare earth ions (III) have a high binding affinity to phosphate groups, while the amine groups can be spontaneously protonated in any aquatic environment causing the depolarization of the bacterial membrane structure via electrostatic forces. Herein, we designed and successfully prepared a new Lanthanum/Cerium synthetic aminoclay analogue (LaCeAC) and studied the in vitro effects in normal and cancer cells. Our results showed a differential effect in each cell line underlying however a common cytotoxic mechanism: the generation of reactive oxygen species (ROS) which was significantly higher and more detrimental to the normal cells. The resilience of cancer cells could be attributed to the milder effect of LaCeAC on their membrane structure, resulting in lower endocytosis (uptake) rates compared to normal cells. | en |
| Τύπος | Peer-Reviewed Journal Publication | en |
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | el |
| Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
| Ημερομηνία | 2025-09-11 | - |
| Ημερομηνία Δημοσίευσης | 2023 | - |
| Θεματική Κατηγορία | Lanthanum/Cerium aminoclay | en |
| Θεματική Κατηγορία | Biocompatibility | en |
| Θεματική Κατηγορία | Cytotoxicity | en |
| Θεματική Κατηγορία | Permeability | en |
| Θεματική Κατηγορία | Cell membrane | en |
| Θεματική Κατηγορία | Oxygen species | en |
| Θεματική Κατηγορία | Reactive | en |
| Βιβλιογραφική Αναφορά | A. S. Kaloudi, A. M. Athinodorou, K. Spyrou, Y. V. Simos, P. Zygouri, M. A. Hammami, K.K.R. Datta, P. Vezyraki, D. Peschos, K. Tsamis, and D. P. Gournis, “Synthesis, characterization, and biocompatibility studies of a new lanthanum-cerium synthetic aminoclay analogue,” Appl. Mater. Today, vol. 35, Dec. 2023, doi: 10.1016/j.apmt.2023.102006. | en |
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