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X-Ray Fluorescence and its application in the analysis of biological materials

Fragkia Ntiana-Maria

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URI: http://purl.tuc.gr/dl/dias/2729A893-1879-4ABE-B743-CFA0E5D5F799
Year 2025
Type of Item Master Thesis
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Bibliographic Citation Ntiana-Maria Fragkia, "X-Ray Fluorescence and its application in the analysis of biological materials", Master Thesis, School of Mineral Resources Engineering, Technical University of Crete, Chania, Greece, 2025 https://doi.org/10.26233/heallink.tuc.104611
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Summary

This Thesis explores the principles and applications of X-Ray fluorescence(XRF) in analyzing biological samples. The research begins with an overview of the X-Ray generation and the fundamental principles governing X-Rays,including their historical development and significance in various fields and particularly in medicine.The study delves into different XRF techniques, such as Energy Dispersive X-Ray Fluorescence (EDXRF) and Total Reflection X-Ray (TXRF), highlighting their advantages and limitations in biological analysis. It emphasizes the unique capabilities of XRF to non-invasively detect trace elements in biological materials, which is crucial for clinical diagnostics, including the assessment of heavy metal exposure and the analysis of calcified tissues like bones and teeth.Furthermore, the thesis compares XRF with other analytical methods,demonstrating its effectiveness in providing elemental composition data that can aid in understanding various health conditions. The research concludes by discussing future directions for enhancing XRF methodologies to improve sensitivity and accuracy in biological sample analysis, underscoring its potential impact on medical diagnostics and research.

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