Institutional Repository
Technical University of Crete
Technical University of Crete
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| URI: | http://purl.tuc.gr/dl/dias/0A87B318-1134-46BF-9BE1-06C3488F3F81 | ||
| Year | 1997 | ||
| Type of Item | Peer-Reviewed Journal Publication | ||
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| Bibliographic Citation | N. Kalogerakis, and L.A. Behie,"Oxygenation capabilities of basket-type bioreactors for microcarrier cultures of anchorage-dependent cells," Bioprocess and Biosystems Engineering, vol. 17, no. 3, pp. 151-156, Jul. 1997. doi: 10.1007/s004490050369 https://doi.org/10.1007/s004490050369 | ||
| Appears in Collections |
The oxygenation capabilities of a new generation three phase - two region 1200 l bioreactor employed for the cultivation of anchorage dependent animal cells were investigated experimentally. A mathematical model has also been developed that explains qualitatively the observed oxygenation characteristics. This type of bioreactor, that uses microcarrier support particles, has two distinct mesh-separated regions so that the air bubbles in the oxygenation region do not come into contact with the microcarriers in the cell (bubble-free) region. Implications on achievable maximum cell densities are also discussed.
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