Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
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| URI | http://purl.tuc.gr/dl/dias/168B9611-2A97-458B-ABFE-80D417FE7C2E | - |
| Αναγνωριστικό | https://doi.org/10.1109/TITB.2010.2072964 | - |
| Γλώσσα | en | - |
| Μέγεθος | 9 pages | en |
| Τίτλος | Complementary gene signature integration in multiplatform microarray experiments | en |
| Δημιουργός | Zervakis Michalis | en |
| Δημιουργός | Ζερβακης Μιχαλης | el |
| Δημιουργός | D. Kafetzopoulos | en |
| Δημιουργός | M.E. Blazadonakis | en |
| Εκδότης | Institute of Electrical and Electronics Engineers | en |
| Περίληψη | The concept of gene signature overlap has been addressed previously in a number of research papers. A common conclusion is the absence of significant overlap. In this paper, we verify the aforementioned fact, but we also assess the issue of similarities not on the gene level, but on the biology level hidden underneath a given signature. We proceed by taking into account the biological knowledge that exists among different signatures, and use it as a means of integrating them and refining their statistical significance on the datasets. In this form, by integrating biological knowledge with information stemming from data distributions, we derive a unified signature that is significantly improved over its predecessors in terms of performance and robustness. Our motive behind this approach is to assess the problem of evaluating different signatures not in a competitive but rather in a complementary manner, where one is treated as a pool of knowledge contributing to a global and unified solution. | en |
| Τύπος | Peer-Reviewed Journal Publication | en |
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | el |
| Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
| Ημερομηνία | 2015-10-24 | - |
| Ημερομηνία Δημοσίευσης | 2010 | - |
| Θεματική Κατηγορία | Biomedicine | en |
| Βιβλιογραφική Αναφορά | M.E. Blazadonakis, M.E. Zervakis, D. Kafetzopoulos ,"Complementary gene signature integration in multiplatform microarray experiments ,"IEEE Trans.s on Inf. Techn. in Biomedicine, vol. 15,no.1,pp.155 - 163,2011.doi:10.1109/TITB.2010.2072964 | en |
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