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Multi-platform data integration in microarray analysis

Zervakis Michail, Sanidas, Elias, Potamias, Georgios, 1953-, Kafetzopoulos Dimitrios , Tsiliki Georgia, Ioannou Marina

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URIhttp://purl.tuc.gr/dl/dias/2FE6CD0E-0F52-4B21-85FF-E225ABD8412B-
Identifierhttps://doi.org/10.1109/TITB.2011.2158232-
Identifierhttps://ieeexplore.ieee.org/document/6083509-
Languageen-
Extent7 pagesen
TitleMulti-platform data integration in microarray analysisen
CreatorZervakis Michailen
CreatorΖερβακης Μιχαηλel
CreatorSanidas, Eliasen
CreatorPotamias, Georgios, 1953-en
CreatorKafetzopoulos Dimitrios en
CreatorTsiliki Georgiaen
CreatorIoannou Marinaen
PublisherInstitute of Electrical and Electronics Engineersen
Content SummaryAn increasing number of studies have profiled gene expressions in tumor specimens using distinct microarray plat forms and analysis techniques. One challenging task is to develop robust statistical models in order to integrate multi-platform findings. We compare some methodologies on the field with respect to estrogen receptor (ER) status, and focus on a unified-among platforms scale implemented by Shen et at. in 2004, which is based on a Bayesian mixture model. Under this scale, we study the ER intensity similarities between four breast cancer datasets derived from various platforms. We evaluate our results with an independent dataset in terms of ER sample classification, given the derived gene ER signatures of the integrated data. We found that integrated multi-platform gene signatures and fold-change variability similarities between different platform measurements can assist the statistical analysis of independent microarray datasets in terms of ER classification. en
Type of ItemPeer-Reviewed Journal Publicationen
Type of ItemΔημοσίευση σε Περιοδικό με Κριτέςel
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2015-10-24-
Date of Publication2011-
SubjectClinical laboratory techniciansen
SubjectMedical laboratory techniciansen
Subjectmedical technologistsen
Subjectclinical laboratory techniciansen
Subjectmedical laboratory techniciansen
Bibliographic CitationG. Tsiliki, M. Zervakis, M. Ioannou, E. Sanidas, E. Stathopoulos and G. Potamias, "Multi-platform data integration in microarray analysis," IEEE Trans. Inf. Techn. Biom., vol. 15, no.6, pp. 806-812, Nov. 2011. doi: 10.1109/TITB.2011.2158232el

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