Institutional Repository
Technical University of Crete
Technical University of Crete
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EL
| URI | http://purl.tuc.gr/dl/dias/28E81428-DDFB-4CE9-B017-F148C35290DA | - |
| Identifier | https://doi.org/10.1109/JBHI.2014.2305770. | - |
| Language | en | - |
| Extent | 11 pages | en |
| Title | Temporal and spatial patterns of gene profiles during chondrogenic differentiation. | en |
| Creator | Zervakis Michalis | en |
| Creator | Ζερβακης Μιχαλης | el |
| Creator | K. Kalantzaki | en |
| Creator | S. Bei | en |
| Creator | G. Skreti | en |
| Publisher | Institute of Electrical and Electronics Engineers | en |
| Content Summary | Clustering analysis based on temporal profile of genes may provide new insights in particular biological processes or conditions. We report such an integrative clustering analysis which is based on the expression patterns but is also influenced by temporal changes. The proposed platform is illustrated with a temporal gene expression dataset comprised of pellet culture-conditioned human primary chondrocytes and human bone marrow-derived mesenchymal stem cells (MSCs). We derived three clusters in each cell type and compared the content of these classes in terms of temporal changes. We further considered the induced biological processes and the gene-interaction networks formed within each cluster and discuss their biological significance. Our proposed methodology provides a consistent tool that facilitates both the statistical and biological validation of temporal profiles through spatial gene network profiles. | en |
| Type of Item | Peer-Reviewed Journal Publication | en |
| Type of Item | Δημοσίευση σε Περιοδικό με Κριτές | el |
| License | http://creativecommons.org/licenses/by/4.0/ | en |
| Date of Item | 2015-10-24 | - |
| Date of Publication | 2014 | - |
| Subject | Biomedical | en |
| Bibliographic Citation | G. Skreti, E.S. Bei, K. Kalantzaki, M. Zervakis ," Temporal and spatial patterns of gene profiles during chondrogenic differentiation ," Biom. and Health Inform. ,vol. 18 ,no.3 ,pp. 799-809,2014.doi:10.1109/JBHI.2014.2305770. | en |
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