Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
EN
|
EL
| URI | http://purl.tuc.gr/dl/dias/D3E583EC-FE3E-4BA0-A03F-98BB19A084F1 | - |
| Αναγνωριστικό | http://www.sciencedirect.com/science/article/pii/S0920996406002969 | - |
| Αναγνωριστικό | https://doi.org/10.1016/j.schres.2006.06.028 | - |
| Γλώσσα | en | - |
| Μέγεθος | 7 pages | en |
| Τίτλος | Small-world networks and disturbed functional connectivity in schizophrenia | en |
| Δημιουργός | Michelogiannis Sifis | en |
| Δημιουργός | Μιχελογιάννης Σήφης | el |
| Δημιουργός | Micheloyannis Sifis | en |
| Δημιουργός | Πάχου Έλλη | el |
| Δημιουργός | Pachou Ellie | en |
| Δημιουργός | Stam Cornelis Jan | en |
| Δημιουργός | Breakspear Michael | en |
| Δημιουργός | Μπίτσιος Παναγιώτης | el |
| Δημιουργός | Bitsios Panagiotis | en |
| Δημιουργός | Βούρκας Μιχαήλ | el |
| Δημιουργός | Vourkas Michael | en |
| Δημιουργός | Ερημάκη Σοφία | el |
| Δημιουργός | Erimaki Sophia | en |
| Δημιουργός | Zervakis Michail | en |
| Δημιουργός | Ζερβακης Μιχαηλ | el |
| Εκδότης | Elsevier | en |
| Περίληψη | Disturbances in “functional connectivity” have been proposed as a major pathophysiological mechanism for schizophrenia, and in particular, for cognitive disorganization. Detection and estimation of these disturbances would be of clinical interest. Here we characterize the spatial pattern of functional connectivity by computing the “synchronization likelihood” (SL) of EEG at rest and during performance of a 2Back working memory task using letters of the alphabet presented on a PC screen in subjects with schizophrenia and healthy controls. The spatial patterns of functional connectivity were then characterized with graph theoretical measures to test whether a disruption of an optimal spatial pattern (“small-world”) of the functional connectivity network underlies schizophrenia. Twenty stabilized patients with schizophrenia, who were able to work, and 20 healthy controls participated in the study. During the working memory (WM) task healthy subjects exhibited small-world properties (a combination of local clustering and high overall integration of the functional networks) in the alpha, beta and gamma bands. These properties were not present in the schizophrenia group. These findings are in accordance with a partially inadequate organization of neuronal networks in subjects with schizophrenia. This method could be helpful for diagnosis and evaluation of the severity of the disease, as well as understanding the pathophysiologic mechanisms underlying cognitive dysfunction in schizophrenia. | en |
| Τύπος | Peer-Reviewed Journal Publication | en |
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | el |
| Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
| Ημερομηνία | 2015-11-19 | - |
| Ημερομηνία Δημοσίευσης | 2006 | - |
| Θεματική Κατηγορία | Schizophrenia | en |
| Θεματική Κατηγορία | EEG | en |
| Θεματική Κατηγορία | Synchronization | en |
| Θεματική Κατηγορία | Functional connectivity | en |
| Θεματική Κατηγορία | “Small-world” networks | en |
| Θεματική Κατηγορία | Working memory | en |
| Θεματική Κατηγορία | Mental illness | en |
| Βιβλιογραφική Αναφορά | S. Micheloyannis, E. Pachou, C. Jan Stam, M. Breakspear, P. Bitsios, M. Vourkas, S. Erimaki and M. Zervakis, "Small-world networks and disturbed functional connectivity in schizophrenia," Schizophrenia Res., vol. 87, no. 1-3, pp. 60-66, Oct. 2006. doi:10.1016/j.schres.2006.06.028 | en |
Copyright © DIAS 2013
