Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
EN  |  EL

Αναζήτηση

Πλοήγηση

Ο Χώρος μου

Azodicarboxylates: valuable reagents for the multicomponent synthesis of novel 1,3,4-thiadiazoles and imidazo[2,1-b][1,3,4]thiadiazoles

Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis, Gernot Buth, Kostakis Georgios

Πλήρης Εγγραφή


URI: http://purl.tuc.gr/dl/dias/C1D7A97B-8880-49B4-AC9E-5A56716EB77C
Έτος 2013
Τύπος Δημοσίευση σε Περιοδικό με Κριτές
Άδεια Χρήσης
Λεπτομέρειες
Βιβλιογραφική Αναφορά T. Zarganes-Tzitzikas, C. G. Neochoritis, J. Stephanidou-Stephanatou, C. A. Tsoleridis, G. Buth, and G. E. Kostakis, "Azodicarboxylates: valuable reagents for the multicomponent synthesis of novel 1,3,4-thiadiazoles and imidazo[2,1-b][1,3,4]thiadiazoles", Tetrahedron, vol. 69, no. 24, pp. 5008-5015, Jun. 2013. doi:10.1016/j.tet.2013.03.096 https://doi.org/10.1016/j.tet.2013.03.096
Εμφανίζεται στις Συλλογές

Περίληψη

Upon reaction of 4,5-disubstituted-N-arylaminoimidazole-2-thiones with isocyanides in the presence of azodicarboxylates (1.2 equiv) at rt, the imidazo[2,1-b][1,3,4]thiadiazoles were formed as the only reaction products in very good yields, whereas by using higher reaction temperatures, along with the imidazo[2,1-b][1,3,4]thiadiazoles, the three component reaction products, namely thiadiazoles, were also isolated, their formation being dependent on the 5-thione substituent. The thiadiazoles became the only reaction products, formed in very good yield by using 2 equiv of azodicarboxylates. The sodium cyanoborohydride and sodium borohydride reductions to thiadiazoles 11, and 12 were also studied. Plausible mechanistic schemes for the formation of the thiadiazoles are proposed.

Υπηρεσίες

Στατιστικά