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Diastereoselective one-pot synthesis of novel ABCD-fused chromeno[2,3-d]pyrazolo[3,4-b]pyridines

Eleni Dimitriadou, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis, Dimitra J. Hadjipavlou-Litina, Christos Kontogiorgis, Kostakis Georgios

Απλή Εγγραφή


URIhttp://purl.tuc.gr/dl/dias/F4F2E829-6960-446F-AF74-1FF401B7FE0E-
Αναγνωριστικόhttp://www.sciencedirect.com/science/article/pii/S0040402014003512-
Αναγνωριστικόhttps://doi.org/10.1016/j.tet.2014.03.031-
Γλώσσαen-
Μέγεθος6 pagesen
ΤίτλοςDiastereoselective one-pot synthesis of novel ABCD-fused chromeno[2,3-d]pyrazolo[3,4-b]pyridinesen
ΔημιουργόςEleni Dimitriadouen
ΔημιουργόςJulia Stephanidou-Stephanatouen
ΔημιουργόςConstantinos A. Tsoleridisen
ΔημιουργόςDimitra J. Hadjipavlou-Litinaen
ΔημιουργόςChristos Kontogiorgisen
ΔημιουργόςKostakis Georgiosen
ΔημιουργόςΚωστακης Γεωργιοςel
ΕκδότηςElsevieren
ΠερίληψηA new aspect concerning chromone chemistry leading to the one-pot synthesis of functionalized novel ABCD-fused chromenopyrazolopyridines has been described. The synthesis involves a multicomponent reaction of chromone-3-benzoylhydrazones with isocyanides and acetylenedicarboxylates, whereupon novel complex tetracyclic benzopyrone derivatives containing three stereogenic centres were formed. The structure elucidation of the products was accomplished by 1D and 2D NMR experiments and confirmed by X-ray crystallographic analysis. Full assignment of all 1H and 13C NMR chemical shifts has been unambiguously achieved. The reaction mechanism is also discussed. In addition, eight chromenopyrazolopyridine derivatives were tested for possible biological activity (antioxidant and lipid peroxidation inhibition).en
ΤύποςPeer-Reviewed Journal Publicationen
ΤύποςΔημοσίευση σε Περιοδικό με Κριτέςel
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2015-12-04-
Ημερομηνία Δημοσίευσης2014-
Θεματική ΚατηγορίαAcetylenedicarboxylatesen
Θεματική ΚατηγορίαChromenesen
Θεματική ΚατηγορίαChromenopyrazolopyridinesen
Θεματική ΚατηγορίαIsocyanidesen
Θεματική ΚατηγορίαMulticomponent reactionsen
Βιβλιογραφική ΑναφοράE. Dimitriadou, J. Stephanidou-Stephanatou, C. A. Tsoleridis, D. J. Hadjipavlou-Litina, C. Kontogiorgis, and G. E. Kostakis, "Diastereoselective one-pot synthesis of novel ABCD-fused chromeno[2,3-d]pyrazolo[3,4-b]pyridines", Tetrahedron, vol. 70, no. 18, pp. 2938-2943, May 2014. doi:10.1016/j.tet.2014.03.031en

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