Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
EN
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EL
| URI | http://purl.tuc.gr/dl/dias/4598B3E8-D09D-4E50-9FE6-5E558D148B9D | - |
| Αναγνωριστικό | https://doi.org/10.26233/heallink.tuc.67216 | - |
| Γλώσσα | en | - |
| Μέγεθος | 112 pages | en |
| Τίτλος | Multiband, dynamic and molecular imaging | en |
| Τίτλος | Πολυφασματική, δυναμική και μοριακή απεικόνιση | el |
| Δημιουργός | Giakoumakis Theodoros-Marios | en |
| Δημιουργός | Γιακουμακης Θεοδωρος-Μαριος | el |
| Συντελεστής [Μέλος Εξεταστικής Επιτροπής] | Zervakis Michalis | en |
| Συντελεστής [Μέλος Εξεταστικής Επιτροπής] | Ζερβακης Μιχαλης | el |
| Συντελεστής [Μέλος Εξεταστικής Επιτροπής] | Garofalakis Minos | en |
| Συντελεστής [Μέλος Εξεταστικής Επιτροπής] | Γαροφαλακης Μινως | el |
| Συντελεστής [Επιβλέπων Καθηγητής] | Balas Costas | en |
| Συντελεστής [Επιβλέπων Καθηγητής] | Μπαλας Κωστας | el |
| Εκδότης | Πολυτεχνείο Κρήτης | el |
| Εκδότης | Technical University of Crete | en |
| Ακαδημαϊκή Μονάδα | Technical University of Crete::School of Electrical and Computer Engineering | en |
| Ακαδημαϊκή Μονάδα | Πολυτεχνείο Κρήτης::Σχολή Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών | el |
| Περιγραφή | Postgraduate Thesis in the School of Electrical and Computer Engineering of Technical University Crete for Master in Electrical and Computer Engineering | en |
| Περίληψη | Tumour heterogeneity describes differences of tumour cells either within the same malignant mass or amongst patients suffering from the same cancer type. It has only recently begun being explored by modern medical science and the repercussions in effective screening and treatment have yet to be fully understood. While research is progressing in search of new biomarkers, there is an increasing tendency to use multiple biomarkers to achieve more precise diagnosis. Under this light, we present a novel multiband bio photonic method and imaging modality capable of imaging in vivo dynamic phenomena and estimating and mapping functional and structural parameters of the observed tissue, fully customizable to record a given set of biomarkers. Complete spectral cube of dynamic phenomena, induced by multiple biomarkers, can be achieved by employing spectral estimation algorithms and single frame simultaneous acquisition of a limited number of spectral bands. The pharmacokinetics of each biomarker can be algorithmically separated, with use of regression algorithms, based on their spectral signature. In silico modeling of the pharmacokinetics of these biomarkers, using compartmental analysis, may adopt sets of biological parameters correlated with the observed response. Previous studies have reported a model of the cervical neoplastic epithelium which predicts the dynamic optical effects after the application of acetic acid. Global optimization analysis has proven that four structural and functional biological parameters correlated with cervical neoplasia can be accurately estimated, with the Differential Evolution (DE) algorithm achieving roughly 99% mean accuracy, as the best performing one. In the scope of this study, we proceed to estimate and map thousands of parameter sets from clinical data, using either DE or a look-up table (LUT) consisting of predefined solutions with at least 92% mean accuracy. The findings agree with literature. Moreover, the use of LUT is vastly time efficient compared to the use of DE, offering estimations within a couple minutes instead of days with similar accuracy levels. The suggested imaging modality can be proven an indispensable tool for reducing time and cost of screening procedures, by providing accurate, quantitative and objective information of biological parameters after the application of multiple biomarkers, while on the same time can be used to further understand dynamic phenomena through real time spectral imaging. | en |
| Τύπος | Μεταπτυχιακή Διατριβή | el |
| Τύπος | Master Thesis | en |
| Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
| Ημερομηνία | 2016-12-27 | - |
| Ημερομηνία Δημοσίευσης | 2016 | - |
| Θεματική Κατηγορία | Cervical intraepithelial neoplasia | en |
| Θεματική Κατηγορία | Inverse problem | en |
| Θεματική Κατηγορία | Global optimisation | en |
| Θεματική Κατηγορία | LookUp table | en |
| Θεματική Κατηγορία | Compartmental modeling | en |
| Θεματική Κατηγορία | Spectral imaging | en |
| Βιβλιογραφική Αναφορά | Theodoros-Marios Giakoumakis, "Multiband, dynamic and molecular imaging", Master Thesis, School of Electrical and Computer Engineering, Technical University of Crete, Chania, Greece, 2016 | en |
| Βιβλιογραφική Αναφορά | Θεόδωρος-Μάριος Γιακουμάκης, "Πολυφασματική, δυναμική και μοριακή απεικόνιση", Μεταπτυχιακή Διατριβή, Σχολή Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών, Πολυτεχνείο Κρήτης, Χανιά, Ελλάς, 2016 | el |
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