URI | http://purl.tuc.gr/dl/dias/340DD917-8765-4E11-8391-96066A8CD6F1 | - |
Αναγνωριστικό | https://www.sciencedirect.com/science/article/abs/pii/S0167876016300198 | - |
Αναγνωριστικό | https://doi.org/10.1016/j.ijpsycho.2016.02.002 | - |
Γλώσσα | en | - |
Μέγεθος | 11 pages | en |
Τίτλος | Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury | en |
Δημιουργός | Antonakakis Marios | en |
Δημιουργός | Αντωνακακης Μαριος | el |
Δημιουργός | Dimitriadis Stavros I. | en |
Δημιουργός | Zervakis Michail | en |
Δημιουργός | Ζερβακης Μιχαηλ | el |
Δημιουργός | Μιχελογιάννης Σήφης | el |
Δημιουργός | Michelogiannis Sifis | en |
Δημιουργός | Micheloyannis Sifis | en |
Δημιουργός | Rezaie Roozbeh | en |
Δημιουργός | Babajani-Feremi Abbas | en |
Δημιουργός | Zouridakis, George | en |
Δημιουργός | Papanicolaou, Andrew C | en |
Εκδότης | Elsevier | en |
Περίληψη | Cross-frequency coupling (CFC) is thought to represent a basic mechanism of functional integration of neural networks across distant brain regions. In this study, we analyzed CFC profiles from resting state Magnetoencephalographic (MEG) recordings obtained from 30 mild traumatic brain injury (mTBI) patients and 50 controls. We used mutual information (MI) to quantify the phase-to-amplitude coupling (PAC) of activity among the recording sensors in six nonoverlapping frequency bands. After forming the CFC-based functional connectivity graphs, we employed a tensor representation and tensor subspace analysis to identify the optimal set of features for subject classification as mTBI or control. Our results showed that controls formed a dense network of stronger local and global connections indicating higher functional integration compared to mTBI patients. Furthermore, mTBI patients could be separated from controls with more than 90% classification accuracy. These findings indicate that analysis of brain networks computed from resting-state MEG with PAC and tensorial representation of connectivity profiles may provide a valuable biomarker for the diagnosis of mTBI. | en |
Τύπος | Peer-Reviewed Journal Publication | en |
Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | el |
Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
Ημερομηνία | 2018-10-16 | - |
Ημερομηνία Δημοσίευσης | 2016 | - |
Θεματική Κατηγορία | Biomarkers | en |
Θεματική Κατηγορία | Cross-frequency coupling | en |
Θεματική Κατηγορία | Magnetoencephalography (MEG) | en |
Θεματική Κατηγορία | Mild traumatic brain injury | en |
Θεματική Κατηγορία | Tensors | en |
Βιβλιογραφική Αναφορά | M. Antonakakis, S. I. Dimitriadis, M. Zervakis, S. Micheloyannis, R. Rezaie, A. Babajani-Feremi, G. Zouridakis and A. C. Papanicolaou, "Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury," Int. J. Psychophysiol., vol. 102, pp. 1-11, Apr. 2016. doi: 10.1016/j.ijpsycho.2016.02.002 | en |