Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
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| URI | http://purl.tuc.gr/dl/dias/0F72CCE3-7DD9-4A39-A7D5-7FC81DAF8554 | - |
| Αναγνωριστικό | https://doi.org/10.3389/fnhum.2021.771668 | - |
| Αναγνωριστικό | https://www.frontiersin.org/articles/10.3389/fnhum.2021.771668/full | - |
| Γλώσσα | en | - |
| Μέγεθος | 11 pages | en |
| Τίτλος | Improving the sensitivity of task-related Functional Magnetic Resonance Imaging data using generalized canonical correlation analysis | en |
| Δημιουργός | Kosteletou Emmanouela | en |
| Δημιουργός | Simos Panagiotis G. | en |
| Δημιουργός | Kavroulakis Eleftherios | en |
| Δημιουργός | Antypa Despina | en |
| Δημιουργός | Maris Thomas G. | en |
| Δημιουργός | Liavas Athanasios | en |
| Δημιουργός | Λιαβας Αθανασιος | el |
| Δημιουργός | Karakasis Paris | en |
| Δημιουργός | Καρακασης Παρις | el |
| Δημιουργός | Papadaki Efrosini | en |
| Εκδότης | Frontiers Media | en |
| Περίληψη | General Linear Modeling (GLM) is the most commonly used method for signal detection in Functional Magnetic Resonance Imaging (fMRI) experiments, despite its main limitation of not taking into consideration common spatial dependencies between voxels. Multivariate analysis methods, such as Generalized Canonical Correlation Analysis (gCCA), have been increasingly employed in fMRI data analysis, due to their ability to overcome this limitation. This study, evaluates the improvement of sensitivity of the GLM, by applying gCCA to fMRI data after standard preprocessing steps. Data from a block-design fMRI experiment was used, where 25 healthy volunteers completed two action observation tasks at 1.5T. Whole brain analysis results indicated that the application of gCCA resulted in significantly higher intensity of activation in several regions in both tasks and helped reveal activation in the primary somatosensory and ventral premotor area, theoretically known to become engaged during action observation. In subject-level ROI analyses, gCCA improved the signal to noise ratio in the averaged timeseries in each preselected ROI, and resulted in increased extent of activation, although peak intensity was considerably higher in just two of them. In conclusion, gCCA is a promising method for improving the sensitivity of conventional statistical modeling in task related fMRI experiments. | en |
| Τύπος | Peer-Reviewed Journal Publication | en |
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | el |
| Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
| Ημερομηνία | 2022-08-04 | - |
| Ημερομηνία Δημοσίευσης | 2021 | - |
| Θεματική Κατηγορία | Task-related fMRI | en |
| Θεματική Κατηγορία | Signal sensitivity | en |
| Θεματική Κατηγορία | fMRI | en |
| Θεματική Κατηγορία | gCCA method | en |
| Θεματική Κατηγορία | Action observation | en |
| Θεματική Κατηγορία | Signal intensity | en |
| Βιβλιογραφική Αναφορά | E. Kosteletou, P.G. Simos, E. Kavroulakis, D. Antypa, T. G. Maris, A. P. Liavas, P. A. Karakasis and E. Papadaki, “Improving the sensitivity of task-related Functional Magnetic Resonance Imaging data using generalized canonical correlation analysis,” Front. Hum. Neurosci., vol. 15, Dec. 2021, doi: 10.3389/fnhum.2021.771668. | en |
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