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Development of a robotic, spectral microscope for the automated microanalysis of massive sample populations

Chousos Christos

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URI: http://purl.tuc.gr/dl/dias/6F4276FC-0844-4D85-B604-E47596308E94
Year 2023
Type of Item Master Thesis
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Bibliographic Citation Christos Chousos, "Development of a robotic, spectral microscope for the automated microanalysis of massive sample populations", Master Thesis, School of Electrical and Computer Engineering, Technical University of Crete, Chania, Greece, 2023 https://doi.org/10.26233/heallink.tuc.96935
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Summary

With the rapid advancement of microscopy, new digital imaging techniques continuously emerge, enriching the visualization of diagnostic features. The existing state-of-the-art machinery, which prioritizes diagnostic performance, is noticeably deficient in terms of automation. As a result, the examination of large volumes of samples at microscopic magnification levels becomes impractical and time-consuming in real-world environments. Consequently, evaluations are limited on randomly selected representative areas, leading to subjectivity and significant discrepancies among observers. The convergence of mechatronics technologies, fast-multichannel imaging sensors, and powerful computational systems offers innovative opportunities for automated multimodal microscopy, thereby achieving enhanced diagnostic performance. This thesis focuses on developing an integrated multimodal high-throughput screening microscope that not only enhances spatial resolution but also combines various analysis and imaging techniques into a single instrument. By harnessing mechatronics technologies and advanced imaging capabilities, the proposed microscope revolutionizes microscopy and analysis, significantly reducing examination time while increasing diagnostic accuracy.

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