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Polymer-gel radiation dosimetry of laser-based relativistic electron sources for biomedical applications: first qualitative results and experimental challenges

Fitilis Ioannis, Grigoriadis Anastasios, Tazes Ioannis, Petrakis Stelios, Andrianaki Georgia, Dimitriou Vasilios, Bakarezos Efthimios, Benis Emmanouil P., Tsiapa Irini, Boursianis Themistoklis, Kalaitzakis Georgios, Bontzos Georgios, Liakopoulos Dimitrios A., Pappas Evangelos, Detorakis Efstathios T., Clark Eugene L., Maris Thomas G., Papadogiannis Nektarios A., Tatarakis, Michael, 19..-

Απλή Εγγραφή

URIhttp://purl.tuc.gr/dl/dias/72D06A5A-4815-4CAB-825F-ECE5E28721C6-
Αναγνωριστικόhttps://doi.org/10.3389/fphy.2022.727511-
Αναγνωριστικόhttps://www.frontiersin.org/articles/10.3389/fphy.2022.727511-
Γλώσσαen-
Μέγεθος15 pagesen
ΤίτλοςPolymer-gel radiation dosimetry of laser-based relativistic electron sources for biomedical applications: first qualitative results and experimental challengesen
ΔημιουργόςFitilis Ioannisen
ΔημιουργόςGrigoriadis Anastasiosen
ΔημιουργόςTazes Ioannisen
ΔημιουργόςPetrakis Steliosen
ΔημιουργόςAndrianaki Georgiaen
ΔημιουργόςΑνδριανακη Γεωργιαel
ΔημιουργόςDimitriou Vasiliosen
ΔημιουργόςBakarezos Efthimiosen
ΔημιουργόςBenis Emmanouil P.en
ΔημιουργόςTsiapa Irinien
ΔημιουργόςBoursianis Themistoklisen
ΔημιουργόςKalaitzakis Georgiosen
ΔημιουργόςBontzos Georgiosen
ΔημιουργόςLiakopoulos Dimitrios A.en
ΔημιουργόςPappas Evangelosen
ΔημιουργόςDetorakis Efstathios T.en
ΔημιουργόςClark Eugene L.en
ΔημιουργόςMaris Thomas G.en
ΔημιουργόςPapadogiannis Nektarios A.en
ΔημιουργόςTatarakis, Michael, 19..-en
ΕκδότηςFrontiers Mediaen
ΠεριγραφήThis work was conducted within the project “Strengthening the competitiveness of the Region of Crete in cutting-edge medical applications using secondary plasma sources from ultra-strong lasers,” funded by national resources of the Public Investment Program of the Region of Crete (KA-2017EP40200006 of SAEP402). We also acknowledge support by the project “ELI—LASERLAB Europe Synergy, HiPER and IPERION-CH.gr” (MIS 5002735) which is implemented under the Action “Reinforcement of the Research and Innovation Infrastructure”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the European Union (European Regional Development Fund).en
ΠερίληψηThe generation of laser based relativistic electron sources involves impressive basic science as well as innovative applications. This study reports first novel qualitative results on polymer-gel radiation dosimetry of ultrafast laser-based relativistic electron beams. The fabricated polymer-gels are irradiated by the ultra-high dose rate (FLASH) laser-generated electron beams and then are analysed using magnetic resonance imaging. The reading of the irradiated dosimeters is performed using a clinical 1.5 T Magnetic Resonance Imaging system. Three-dimensional colour parametric T2 maps are then constructed from the original PD-T2 weighted images obtained from the clinical MRI scanner. For comparison, the gels are also irradiated with standard electron beams of various energies utilizing a radiotherapy clinical linear accelerator system. For the calibration measurements of the gel dosimetry method, special calibrated dosimetric films are also implemented. The preliminary results demonstrate the potential of polymer gel dosimetry for 3D-dose-distribution of FLASH type irradiation of laser generated electron beams. Furthermore, they illustrate potential issues related to the polymer gel based dosimetry in challenging irradiation arrangements, such as the oxygen sensitivity and necessity for oxygen impermeable container material.en
ΤύποςPeer-Reviewed Journal Publicationen
ΤύποςΔημοσίευση σε Περιοδικό με Κριτέςel
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2024-03-05-
Ημερομηνία Δημοσίευσης2022-
Θεματική ΚατηγορίαPhantom polymer gelen
Θεματική ΚατηγορίαLaser accelerationen
Θεματική ΚατηγορίαRadiation dosimetryen
Θεματική ΚατηγορίαBiomedical applicationen
Θεματική ΚατηγορίαFLASH radiationen
Βιβλιογραφική ΑναφοράI. Fitilis, A. Grigoriadis, I. Tazes, S. Petrakis, G. Andrianaki, V. Dimitriou, E. Bakarezos, E. P. Benis, I. Tsiapa, Τ. Boursianis, G. Kalaitzakis, G. Bontzos, D. A. Liakopoulos, E. Pappas, E. T. Detorakis, E. L. Clark, T.G. Maris, N.A. Papadogiannis and M. Tatarakis “Polymer-gel radiation dosimetry of laser-based relativistic electron sources for biomedical applications: first qualitative results and experimental challenges,” Front. Phys., vol. 10, Apr. 2022, doi: 10.3389/fphy.2022.727511.en

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