Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
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| URI: | http://purl.tuc.gr/dl/dias/2C2A35DF-0DA9-4360-B3A3-FA49ECE089FE | ||
| Έτος | 2012 | ||
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | ||
| Άδεια Χρήσης |
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| Βιβλιογραφική Αναφορά | A. Zaal, J. A. Louwers, J. Berkhof, M. Kocken, W.A. Harmsel, G.C.M. Graziosi, J. W.M. Spruijt, C. Balas, E. Papagiannakis, P. J. F. Snijders, C.J.L.M. Meijer, F.J. van Kemenade, R. H. M. Verheijen. "Agreement between colposcopic impression and histological diagnosis among HPV16 positive women: a clinical trial using dynamic spectral imaging colposcopy". BJOG. Feb. 2012, Vol. 119, Iss. 5, pp. 537-44. DOI: 10.1111/j.1471-0528.2012.03280 https://doi.org/10.1111/j.1471-0528.2012.03280.x | ||
| Εμφανίζεται στις Συλλογές |
To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16-positive (HPV16(+)) and non-16 high-risk (hr) HPV(+) women.Prospective, comparative, multicentre clinical trial.Three colposcopy clinics in the Netherlands.Women (n = 177) aged 18 years or over with an intact cervix, referred for colposcopy.The colposcopist graded the lesion by using the DSI colposcope as a regular video colposcope. Subsequently the DSI impression was displayed and biopsies were taken from all abnormal areas as well as from a random (normal) site. A cervical smear was taken for HPV typing.Histologically confirmed high-grade cervical intraepithelial neoplasia or cancer (CIN2(+)), positive for HPV16 or for any other hrHPV type.The DSI colposcope identified more CIN2(+) cervical lesions among HPV16(+) women than in non-16 hrHPV(+) women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2(+)). Consequently, the sensitivity of the DSI colposcope for detecting CIN2(+) lesions was higher in HPV16(+) women than in non-16 hrHPV(+) women (97% versus 74%, P = 0.009). No such differences were seen for the colposcopist impression. In addition, mainly smaller cervical lesions are missed by the colposcopist.The sensitivity of DSI colposcopy for CIN2(+) is higher in HPV16(+) than in non-16 hrHPV(+) women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2(+) is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions.
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