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CXCR4 pathways in CTCs: from bioinformatics to immunophenotype

D. Mavroudis, G. Kallergi, S. Sfakianakis, V. Georgoulias, Zervakis Michalis

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URI: http://purl.tuc.gr/dl/dias/684CEBC7-1B19-4DF5-B522-CFB934FB9684
Year 2015
Type of Item Peer-Reviewed Journal Publication
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Bibliographic Citation G. Kallergi, V. Tsintari, S. Sfakianakis, M. Zervakis, D. Mavroudis, V. Georgoulias ,"CXCR4 pathways in CTCs: from bioinformatics to immunophenotype,"Cancer Res.,vol.75,no.15, pp.1592-1592,2015.doi:10.1158/1538-7445.AM2015-1592 https://doi.org/10.1158/1538-7445.AM2015-1592
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Journal Publications in Community School of Electrical and Computer Engineering

Summary

Bioinformatics' analysis regarding gene expression in Normal tissue vs cancer tissue, Normal blood vs cancer patients' blood and Normal blood vs cancer tissue revealed a subgroup of 24 genes which potentially could be overexpressed in CTCs. Among these genes are: CXCR4, a chemokine receptor which is involved in tumor metastasis and, JUNB a transcription factor participating in CXCR4 pathway.

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