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Involvement of tgf-a, rock1, dock2 and caveolin-1 in osteoarthritis pathogenesis

Zervakis Michalis, D. Kafetzopoulos, Kalantzaki Kalliopi, E. Chatziliadou, S. Dubos

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URI: http://purl.tuc.gr/dl/dias/F2DCDF11-38E7-485D-B76D-ED2712E0D888
Year 2014
Type of Item Peer-Reviewed Journal Publication
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Bibliographic Citation V. Papanikolaou, V. Gkretsi, K. Malizos, E. Chatziliadou, S. Dubos, M. Zervakis, D. Kafetzopoulos, K. Kalantzaki, A. Bei, L. Takacs, C. Zoumadakis, A. Tsezou ,"Involvement of tgf-a, rock1, dock2 and caveolin-1 in osteoarthritis pathogenesis,"Ost. and Cartilage ,vol.22,2014. doi:10.1016%2Fj.joca.2014.02.270 https://doi.org/10.1016/j.joca.2014.02.270
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Summary

Osteoarthritis (OA) is a debilitating disease of the joints characterized by cartilage degradation. To date there is no available pharmacological treatment to inhibit disease progression neither is there a suitable biomarker for early disease prognosis. The aim of the present study was to investigate the molecular pathways involved between four identified OA susceptibility genes and their role in OA pathogenesis.

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