Ιδρυματικό Αποθετήριο
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
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| URI: | http://purl.tuc.gr/dl/dias/6E44BEF3-7963-4AD1-8842-6628EA83474E | ||
| Έτος | 2011 | ||
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | ||
| Άδεια Χρήσης |
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| Βιβλιογραφική Αναφορά | J. A. Louwers, A. Zaal, M. Kocken, W.A. ter Harmsel, G.C.M. Graziosi, J.W.M. Spruijt, J.Berkhof, C. Balas, E. Papagiannakis, P. J. F. Snijders, C.J.L.M. Meijer, F. J. van Kemenade, R. H. M. Verheijen "Dynamic Spectral Imaging Colposcopy: Higher sensitivity for detection of premalignant cervical lesions" BJOG. Feb. 2011, Vol. 118, Iss. 3, pp. 309-18, doi: 10.1111/j.1471-0528.2010.02806.x https://doi.org/10.1111/j.1471-0528.2010.02806.x. | ||
| Εμφανίζεται στις Συλλογές |
OBJECTIVE:to validate the dynamic spectral imaging (DSI) colposcope's colour-coded map in discriminating high- from low-grade cervical lesions and non-neoplastic tissue.DESIGN:prospective, comparative, multicentre clinical trial.SETTING:the colposcopy clinics of three Dutch hospitals.POPULATION:women of 18 years or over with an intact cervix, referred for colposcopy.METHODS:during a 3-minute image acquisition phase, the DSI colposcope was used as a regular video colposcope: the colposcopist located and graded potential lesions based on conventional colposcopic criteria. Subsequently, a colour-coded map was calculated and displayed, representing localisation and severity of the cervical lesion. Biopsies were collected from all atypical sites, as identified by digital mapping and/or conventional colposcopy. Furthermore, one additional biopsy was taken.MAIN OUTCOME MEASURES:histologically confirmed high-grade cervical disease (CIN2+).RESULTS:in total 275 women were included in the study: 183 women were analysed in the 'according-to-protocol' (ATP) cohort and 239 women in the 'intention-to-treat' (ITT) cohort. In the ATP cohort, the sensitivity of DSI colposcopy to identify women with high-grade (CIN2+) lesions was 79% (95% CI 70-88) and the sensitivity of conventional colposcopy was 55% (95% CI 44-65) (P = 0.0006, asymptotic McNemar test). When the DSI colour-coded map was combined with conventional colposcopy, the sensitivity was 88% (95% CI 82-95).CONCLUSIONS:DSI colposcopy has a significantly higher sensitivity to detect cervical lesions than conventional colposcopy. If the colour-coded map is combined with conventional colposcopic examination, the sensitivity increases further.
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