Institutional Repository
Technical University of Crete
Technical University of Crete
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| URI: | http://purl.tuc.gr/dl/dias/AC0EB294-A074-48E3-9FD4-0524AEB1B0D8 | ||
| Year | 2012 | ||
| Type of Item | Peer-Reviewed Journal Publication | ||
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| Bibliographic Citation | G. Papoutsoglou, M. Stamatiadou, C. Balas "In silico modeling and global optimization of dynamic bio-optical processes for probing, in vivo, biological features of neoplasia" IEEE-iCBCB 2012, Macau, China May 28-30, 2012,DOI:10.1109/iCBEB.2012.474 https://doi.org/10.1109/iCBEB.2012.474 | ||
| Appears in Collections |
We present the first in silico simulation of biomarker uptake kinetics and of the associated dynamic optical signals, measured in vivo in neoplastic epithelial tissue. We introduce a new, non-invasive method for estimating and mapping of both structural and functional, neoplasia-correlated parameters. The method relies on model-based fitting of dynamic optical signals, measured in vivo, and on solving the inverse problem with the aid of global sensitivity analysis and global optimization approaches.
Copyright © DIAS 2013
